Officers were called to reports of a serious collision in the A616 between Mill Lane and Manor Road last night (16 February 2017).
The call came in just after 10pm about a crash between a car, van and lorry.
A 64-year-old woman and a 38-year-old man were taken to hospital with injuries thought to be serious.
A 25-year-old woman and a 17-year-old boy were also taken to hospital and treated for injuries not thought to be serious.
The road remained closed until 8.30am on 17 February 2017 while inquiries took place.
Investigators would be interested in speaking to the driver of a lorry which is understood to have sustained minor damage in relation to the collision but may not have been aware of this at the time.
If you witnessed the incident or have any information which may assist, please call Nottinghamshire Police on 101 quoting incident number 947 of 16 February 2017.