Nottinghamshire Police and Crime Commissioner Caroline Henry continues to be fully briefed by the Chief Constable on the ongoing situation in the city centre.
Police were called to Ilkeston Road just after 4 am where two people were found dead in the street.
Officers were then called to another incident in Milton Street where a van had attempted to run over three people. They are currently being treated in hospital.
A man has also been found dead on Magdala Road.
Police have arrested a 31-year-old man on suspicion of murder and he remains in police custody.
“This is a truly shocking and tragic incident and my thoughts are with the loved ones of the three people who have been killed and those who have been injured,” said Commissioner Henry.
“The fact that a man is already in custody in connection with this is really reassuring and I give my heartfelt thanks to all of the police officers and staff involved. It is at times like this that we really appreciate the dedication and professionalism of the police and partner agencies in keeping people safe.
“The force is working tirelessly to investigate the incident and we really appreciate the patience of the public at this time while parts of the city centre are closed.”