Emergency services were called after a report of a serious collision involving a child.
Police have closed all of Torkard Way between Station Road and Baker Street in Hucknall following the incident at around 3.50pm on Thursday (10 June 2021).
There is expected to be traffic disruption while emergency services work at the scene.
Police Sergeant Michael Corey of Nottinghamshire Police said: “We are working hard to understand exactly what happened.
“The child has been taken to hospital in the air ambulance and her injuries have been described as life-altering.
“If you witnessed this incident or have any information please call us on 101, quoting incident 551 of 10 June 2021.
“We’d also like to hear from any drivers who may have recorded dash-cam footage or any local residents who may have CCTV footage which could help us with our investigation.”