The force was called to reports of a collision between a car and a motorcycle on the A57 Snake Pass at 11.20am today (31 March).
At the scene the rider of a blue Suzuki motorcycle was pronounced deceased. His family are aware.
The driver of the car, a Kia Picanto, were not seriously injured.
The road was closed following the collision and reopened at 8.40pm.
Anyone who was in the area and may be able to assist officers with their investigation – in particular anyone with dashcam footage that may have captured the moments prior to the collision – is asked to contact us using any of the below methods, including reference 24000187594: